In this study, we performed bioinformatic analysis to show that CBX7 and CBX6 functioned as protective factors with hazard ratios (HRs) less than 1 but CBX8 and CBX4 functioned as risk factors with HRs greater than 1 in renal cell carcinoma (Fig. 1A). The gene discussed is CBX4; the disease is hereditary clear cell renal cell carcinoma.