CBX4 and hereditary clear cell renal cell carcinoma: Since the cancer-related role of the CBX family in renal cell carcinoma is unknown, we first performed bioinformatic analysis and found that CBX7 and CBX6 functioned as protective factors with hazard ratios (HRs) less than 1 but CBX8 and CBX4 functioned as risk factors with HRs greater than 1 in renal cell carcinoma (Fig. 1A).