IL6 and nonpapillary renal cell carcinoma: Although knockdown/overexpression of CBX7 increased/decreased IL6 expression in ccRCC cells (Fig. 4I, J,Supplementary Fig. 2C,2D), ChIP-seq of CBX7 demonstrated that CBX7 did not directly bind to the promoter region of IL6 (Supplementary Fig. 2E).