Subsequent correlation analysis showed that PLIN4, RGS4, SLC2A3, SLC2A14, HIC1, DUSP1, CDO1, NOX4 and SLC2A6 displayed negative correlation with CD8+ T cytotoxicity score and positive correlation with myofibroblasts as well as EMT gene score (Figure S7D), suggesting these genes could contribute to the suppressive tumor microenvironment. The gene discussed is HIC1; the disease is neoplasm.