Subsequent correlation analysis showed that PLIN4, RGS4, SLC2A3, SLC2A14, HIC1, DUSP1, CDO1, NOX4 and SLC2A6 displayed negative correlation with CD8+ T cytotoxicity score and positive correlation with myofibroblasts as well as EMT gene score (Figure S7D), suggesting these genes could contribute to the suppressive tumor microenvironment. This evidence concerns the gene RGS4 and neoplasm.