Furthermore, in primary PM-CRC tumors, αSMA+ CAFs were present at a higher relative abundance (a higher proportion of the αSMA+ area) (Fig. 2B), and high αSMA+ (ACTA2) expression was associated with poor prognosis in CRC patients based on analysis of data from the TCGA database (Fig. 2C). Here, ACTA1 is linked to colorectal carcinoma.