Enrichment of SHIP2 by immunoprecipitation from cultured myotubes and hepatoma cells followed by the measurement of the phosphatase activity in the precipitate revealed that 10 μM ebselen reduces SHIP2 activity by approximately 50% in both cell types (Figure 1C, D) without affecting SHIP2 expression level (Supplementary Figure S1A-D). The gene discussed is INPPL1; the disease is hepatocellular carcinoma.