Lipid phosphatase SHIP2 serves a target to treat insulin resistance, as it suppresses phosphatidylinositol 3-kinase (PI3K)-mediated insulin signaling pathway by hydrolyzing phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) 4, 5. The gene discussed is INS; the disease is Insulin resistance.