CEACAM5 and metastatic malignant neoplasm in the lymph nodes: We analyzed circRAPGEF5 expression and the clinical data of LAD patients and found that circRAPGEF5 was related to sex and lymph node metastasis (Table 1), but had no significant correlation with age, tumor size, T stage, M stage, and serum carcinoembryonic antigen (CEA).