PROM1 and cancer: In order to determine whether CSCs could originate from normal liver progenitor cells (LPC) and their involvement in liver carcinogenesis, we used the public cBioPortal site for web-based analysis of Liver Hepatocellular Carcinoma (TCGA PanCancer Atlas) and Spearman's correlation coefficient to assess the relationship between the mRNA expression levels of the classically used cancer stem cell marker CD133 (alias PROM1) and other genes 23, 24.