In this study, we evidenced that IL-17 promotes LPC stem-cell features and conversely attenuates their hepatocytic differentiation, by promoting mitogenic pathways and de-differentiation through miR-122 downregulation (Figure 8).  As a conclusion, our study sheds light on how IL-17 cytokine could initiate primary liver cancer by transforming normal LPCs into tumor initiating cells through epigenetic reprogramming. Here, IL17A is linked to liver cancer.