The increase of urinary albumin excretion and the severity of podocyte and glomerular injury in Cre+/MAD2Bfl/fl diabetic mice were significantly less than Cre-/MAD2Bfl/fl diabetic mice, indicating that podocyte-specific MAD2B deletion alleviates podocyte injury in DN. This evidence concerns the gene MAD2L2 and liver dysplastic nodule.