Results showed that SENP1 down-regulation led to significantly decrease in ZEB1 and CSN5 expression (Fig. 7I-L), reduced tumor size and light tumor weight (Fig. 7A, D), slower tumor growth (Fig. 7B), less lung metastasized lymph nodes and reduced lung weight (Fig. 7 E-G), while the overall mouse weight within each group was not significantly changed (Fig. 7C). This evidence concerns the gene ZEB1 and neoplasm.