VEGFA and preeclampsia: Here, we draw attention to the well-known magnesium-lowering effects of PPIs occurring after long-term treatment.12 Low magnesium levels, combined with the lower expression of the Mg2+-transporting transient receptor potential melastatin-subfamily member 7 in preeclamptic placentas, have been suggested to result in lower vascular endothelial growth factor expression.13 Although this concept provides a mechanistic basis for the therapeutic use of MgSO4 in preeclampsia, definite proof for this theory is lacking.