Guo et al. (2020) found that BI could inhibit hepatocellular carcinoma proliferation, migration, and invasion through targeting mTOR signaling. In human hepatocellular carcinoma cell lines, BI inhibited tumor proliferation by inducing apoptosis and reducing the NF-κB signaling pathway. It was also reported that BI suppressed metastasis and epithelial–mesenchymal transition of nasopharyngeal carcinoma by targeting the hedgehog pathway (Wang et al., 2021). However, there is little research about BI in MM. Kim et al. (2011) presented that BI inhibits multiple myeloma by inducing cell apoptosis. Here, NFKB1 is linked to hepatocellular carcinoma.