RAF1 and yang deficiency: As shown in Figures 6(a) and 6(b), the key genes in ME-yellow of the Yang deficiency group were KAT2B, NFKB2, CREBBP, and GTF2H3, while JUNB, JUND, NGLY1, TNF, RAF1, and PPP1R15A were the key genes in ME-green of the Yin deficiency group.