We herein showed that JDYZF reduced the protein expression levels of NLRP3, pro-caspase-1, and caspase-1 P20 in the hippocampi of AD rats and inhibited the excessive activation of NLRP3 inflammasomes, thereby inhibiting the maturation of GSDMD, breaking the vicious cycle between Aβ and pyroptosis and improving cognitive impairment in AD rats. Here, NLRP3 is linked to Cognitive impairment.