Li et al. [21] showed that Huaier polysaccharide (TP-1) is the main active component of Huaier granules, which inhibits the hypoxia-inducible factor (HIF)-1 alpha/vascular endothelial growth factor (VEGF) and RNA binding factor-1 (AUF-1)/astrocyte elevated gene-1 (AEG-1) signaling pathway and plays an antihepatic tumor and antimetastasis effect in liver cancer. This evidence concerns the gene MTDH and liver cancer.