Pan et al. [24] showed that Ganfule capsules can regulate phosphatidylinositol 3-kinase catalytic alpha (PIK3CA) and caspase-8 (CASP8) protein expression, thus indirectly affecting the PI3K-Akt/JAkt-STAT signal transduction pathway and inhibiting the proliferation and invasion of human liver cancer HepG2 cells. This evidence concerns the gene CASP8 and liver cancer.