We have revealed, for the first time, through this study that LIQ inhibits cardiac hypertrophy by downregulating the expression of ATE1 and the phosphorylation of TAK1 and JNK1/2 (Figures 3(a)–3(d)), which inhibits the mRNA expression of hypertrophy-related markers ANP, BNP, and β-MHC (Figures 2(a)–2(e)). Here, MAPK8 is linked to cardiac hypertrophy.