The top four pathways were the FOXO signaling pathway (AKT1/CAT/EGF/EGFR/IGF1/IL-10/IL-6/INS/MAPK8/STAT3), Yersinia infection (AKT1/CCL2/IL-10/IL-1B/IL-6/JUN/MAPK8/TLR4/TNF), TNF signaling pathway (AKT1/CCL2/ICAM1/IL-1B/IL-6/JUN/MAPK8/MMP9/TNF), and HIF-1 signaling pathway (AKT1/EGF/EGFR/GAPDH/IGF1/IL-6/INS/STAT3/TLR4). The gene discussed is ICAM1; the disease is Yersinia infectious disease.