Although studies have reported the role of Dicer1 (Tinarelli et al., 2014), Xbp1 (Brown, Strus & Naidoo, 2017), Crem (Wimmer et al., 2021), and Naglu (Değerliyurt et al., 2021) in SD, their relationship with memory remains unclear, as well as their relationship with immunity. Here, XBP1 is linked to Salla disease.