COVID-19 lethality had been associated with hereditary errors of Toll-like receptor 3- (TLR3-) and interferon regulatory factor- (IRF7-) dependent type I interferon (IFN) immunity [13] and, strikingly, the presence of neutralizing IgG autoantibodies against IFN-ω, IFN-α, or both at the earlier stages of the disease. The gene discussed is TLR3; the disease is COVID-19.