Our study revealed that hospitalization days ≥7 days, number of admissions ≥2 times, surgery, chemotherapy, the type of antibiotics used ≥2 species, albumin <40.0 g/L, and prealbumin <0.2 g/L were associated with E. coli BSI of pancreatic cancer patients; gender, age, clinical stage, intraoperative bleeding, radiotherapy, and other characteristics were not the potential risk factors for pancreatic cancer patients with E. coli BSI (P ≥ 0.1). This evidence concerns the gene ALB and familial pancreatic carcinoma.