Remarkably, the combination of IL-17A and Claudin-1 (AUC: 0.741, p = 0.0067) almost performed identically to Claudin-1 alone (AUC: 0.741, p = 0.0045), while IL-17A (AUC: 0.590, p = 0.3126) had poor performance separating early-onset psoriasis from late-onset psoriasis (Supplementary Table 5 and Figure 3(b)). The gene discussed is CLDN1; the disease is psoriasis.