In the previous studies, Rahimian and Çevik have found that S100-β was more sensitive and appeared during the early phase of mTBI, which was more befitting for the early diagnosis of mTBI than other biomarkers (Vos et al., 2010; Thelin et al., 2013; Çevik et al., 2019; Rahimian et al., 2020). Here, S100B is linked to concussion.