This suggests that in critical COVID-19, strong elevation of IL-6 (e.g., > 100-120 pg/mL) and CRP levels (e.g., > 160-200 mg/L) could reflect augmented IL-6 cis-signalling in the attempt to exert homeostatic roles, while IL-10 further strengthens the predominance of SOCS3 over STAT3 signal (36). The gene discussed is IL10; the disease is COVID-19.