Altogether, COVID-19 patients characterised by serum ferritin levels > 1600-2000 ng/mL, LDH > 500-550 U/L, and D-dimer > 3000-5000 ng/mL, are most likely hyperinflamed and critically-ill patients who do not respond to IL-6R blockade (but may still respond to IL-1 blockade). The gene discussed is IL1A; the disease is COVID-19.