From the literature, we identified 10 retrospective cohort studies, published between May 9, 2020, and January 8, 2021, that enrolled patients hospitalised with COVID-19 during the “first wave” of the outbreak in Italy (overall between the end of February and the end of May, 2020), who underwent treatment with IL-6 inhibitors versus standard of care only (45–54). This evidence concerns the gene IL6 and COVID-19.