In fact, our data suggest that during the gastric carcinogenic process, there is an increase in the levels of ECM components responsible for growth factor binding, particularly to TGF-β superfamily molecules, potentiating TGF-β-driven tumor growth and invasion, evasion of immune surveillance, cancer cell dissemination and future metastasis (Massagué, 2008). The gene discussed is TGFB1; the disease is neoplasm.