Interestingly, co-expression of COL1A2 and LOX—whose expression in the TCGA-STAD database is highly correlated (Pearson’s correlation coefficient = 0.87, p-value = 6.21e-83)—promotes cancer drug-resistance by increasing collagen cross linking, consequently, stiffening the extracellular matrix and blocking drug diffusion (Di Paolo and Bocci, 2007; Sterzyńska et al., 2018). The gene discussed is LOX; the disease is cancer.