Regarding downregulated tumor ECM constituents, we identified the basement membrane components collagen alpha-5(IV) chain (COL4A5), collagen alpha-6(IV) chain (COL4A6), collagen alpha-1 (XXVIII) chain (COL28A1), laminin subunit alpha-5 (LAMA5), nidogen 1 (NID1), proteoglycans osteoglycin (OGN) and decorin (DCN), ECM regulators alpha-1-microgobulin/bikunin precursor (AMBP) and secretory leucocyte protease inhibitor (SLPI), along with secreted factor protein Wnt-2b (WNT2B). This evidence concerns the gene COL28A1 and neoplasm.