The glycoproteins EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) and von Willebrand factor (vWF) were present in tumor and normal adjacent tissue but not in the normal distant mucosa matrisome and, surprisingly, there was only one tumor-specific protein, collagen alpha-1(X) chain (COL10A1). Here, EFEMP2 is linked to neoplasm.