In fact, we were able to detect five upregulated proteins in the normal mucosa adjacent to the tumor, namely laminin subunit alpha-4 (LAMA4), elastin microfibril interfacer 1 (EMILIN1), LTBP1 and fibrinogen beta chain (FGB), as well as proteoglycan versican core protein (VCAN). This evidence concerns the gene LTBP1 and neoplasm.