CASP1 and necrotizing enterocolitis: The qRT-PCR assay manifested that the mRNA levels of NLRP3, TLR4, NF-κB, and caspase-1 of the terminal ileum tissues in NEC mice were prominently upregulated, while the elevated effects were partially offset by MEL treatment (Figures 5(a)–5(d), P < 0.01).