Hereditary Xerocytosis, a familial anemia, is caused by a gain-of-function mutation in Piezo1 characterized by slowed inactivation resulting from three missense mutations and one recurrent duplication in the Piezo1 gene, with all mutations located at the C-terminal half of Piezo1 (Albuisson et al. 2013). Here, PIEZO1 is linked to anemia (phenotype).