In addition, TNF-α also induces extracellular matrix (ECM) remodeling by regulating the expression of MMPs involved in joint damage in RA, as well as expression of multiple chemokines including IL-8, MCP-1, CCL3, CCL4, and RANTES, which contribute to chronic inflammatory [9–16]. Here, CXCL8 is linked to rheumatoid arthritis.