Additionally, HbA1c levels strongly depend on the turnover of red blood cells: slow turnover (e.g., in iron, vitamin B12, or folate deficiency anemias) often results in higher, whereas fast turnover (e.g., hemolytic anemia and erythropoietin therapy) leading to lower HbA1c levels [31–37, 44]. The gene discussed is EPO; the disease is folic acid deficiency anemia.