PS ECOG - Eastern Cooperative Oncology Group Performance Status Scale; IMDC - International Metastatic Renal Cell Carcinoma Database Consortium; TKIs - tyrosine kinase inhibitors; mTORis - mammalian target of rapamycin inhibitors; NER - neutrophil-to-eosinophil ratio; irAE - immune-related adverse events. This evidence concerns the gene MTOR and hereditary clear cell renal cell carcinoma.