On the other hand, because activity and CaV1.1 control MuSK (Valenzuela et al., 1995; Tang and Goldman, 2006; Chen et al., 2011; Kaplan et al., 2018) and integrin β1 expression (Figure 1A), and because it has been recently shown that integrin-LRP4/MuSK pathways regulate YAP phosphorylation and activity through the Hippo pathway in liver cancer development (Chakraborty et al., 2017), it is possible that integrins and MuSK represent activity-dependent regulators of YAP signaling also in skeletal muscle. Here, LRP4 is linked to liver cancer.