Figure 4 shows the results of univariate Cox regression analysis, indicating that several factors (e.g., higher T stage (T3 and T4), higher N stage (N1 and N2), higher M stage (M0), higher pathologic stage (Stage III and Stage IV), primary therapy outcome (PD and SD), age, residual tumor (R1 and R2), CEA level (>5), lymphatic invasion (yes), and low level of GCG expression) were negative predictors for overall survival outcome in COADREAD patients. Here, GCG is linked to neoplasm.