The CEJ-ABC distance in the ETC-1002 group was 58.9% than that in the periodontitis group (Figures 4(b2), 4(b3) and 4(c), P < 0.05); however, when Compound C, an AMPK inhibitor, was coadministered with ETC-1002, the CEJ-ABC distance was 1.27-fold greater than that seen in the ETC-1002 group (Figures 4(b3), 4(b4), and 4(c), P < 0.01). The gene discussed is PRKAA1; the disease is periodontitis.