Due to damage, stress and inflammatory mediators that can be caused by toxic substances to cells, HMGB1 will be expressed both intracellularly and extracellularly with end results involved some cytokines in infection condition [[57], [58], [59], [60], [61], [62], [63]], metabolic disorder [64], allergy [65,66] and traumatic injury [[67], [68], [69], [70]]. The gene discussed is HMGB1; the disease is metabolic disease.