AGER and Myocardial fibrosis: Activation of NFκB promotes the expression of proinflammatory cytokines, including RAGE expression, to induce prolonged activation and promotion of signaling mechanisms of cardiomyocyte damage, collagen deposition, fibrinolysis, and myocardial fibrosis through complex mechanisms such as angiogenesis, increased vascular permeability, vascular occlusion, and cell degeneration.