With relevance to iron metabolism, it has been documented that any perturbation of the membrane potential and of ion channels lead also to an altered ferroportin function.227 In COVID-19 this possible functional alteration of the membrane, and specifically of ferroportin, contributes furthermore to the intracellular ferritin accumulation, also in view of the deregulated axis with hepcidin. Here, HAMP is linked to COVID-19.