BSG and COVID-19: A long series of publications have regarded the possible SARS-CoV-2 interaction with erythrocytes and the consequent hemoglobin dysfunction, with release of free circulating hemoglobin/heme.21,22,128,132,240,241 More importantly, a few researchers highlighted clear erythrocyte membrane alterations in COVID-19 patients.4 These and previous data seem to demonstrate furthermore the CD147/SA-based interaction of SARS-CoV-2 with RBC which, at least partially, explains the consequent hemoglobin/iron cycle alteration.