MAPK3 and COVID-19: In summary, our study found that active ingredients such as luteolin, naringenin, farnesin, kaempferol, and quercetin can act on targets such as TNF, GAPDH, MAPK3, MAPK1, EGFR, CASP3, MAPK8, MTOR, IL-2, and MAPK14 to regulate signaling pathways such as Kaposi sarcoma-associated herpesvirus infection and AGE-RAGE, finally achieving the effect of curing COVID-19.