ANLN and urinary bladder cancer: For example, molecular pathways related to epithelial and epidermal cell differentiation are activated after ANLN knockout in breast cancer cells [35]; ECM adhesion and actin cytoskeleton pathways are dysregulated in pancreatic cells, which is consistent with the decreased cell motility following ANLN depletion in these cells [13]; changes of other noncanonical pathways like Toll-like receptor and cytokine signaling are also observed in bladder cancer cells [11].