MMP2 and osteoarthritis: In line with our findings, a prior study came across the ability of GAS5 to increase both the expressions of MMP2/3/9/13 and ADAMTS4 and further induce apoptosis in the setting of osteoarthritis pathogenesis [12], whereas its silencing is known to inactivate caspase-3 to resist cell apoptosis in neurons induced by oxygen-glucose deprivation, wherein GAS5 acts as a ceRNA of miR-137 [41].