PGC-1α is essential for the induction of ROS-detoxifying enzymes such as glutathione peroxidase and SOD2 under oxidative stress, PGC-1α null mice were sensitive to oxidative stress [37]; PGC-1α inhibited mitochondrial oxidative stress by facilitating Nrf2 binding to antioxidant response element promoter site and inducing SOD2 expression in sepsis [38]. The gene discussed is PPARGC1A; the disease is Sepsis.