Hyperglycemia impairs Nrf2 binding at Gclc-ARE4 due to increased H3K4me2 and decreased H3K4me1/me3 in retinal endothelial cells and the retinas of rats and human donors with diabetes, and silencing LSD1 ameliorates the decrease in H3K4me1 and prevents the biosynthesis of GSH in diabetic retinopathy [70]. This evidence concerns the gene KDM1A and diabetic retinopathy.