For example, H3K4 monomethylated by Set7 regulates the expression of COX-2 and iNOS by binding to the NF-κBp65 promoter in peripheral blood monocytes (PBMs) from patients with type 2 diabetes mellitus (T2DM), thus inducing ROS and inflammatory factor production [50]. This evidence concerns the gene NOS2 and type 2 diabetes mellitus.