Moreover, the transcription of keap1 is modulated by H3K4me1, and the keap1/Nrf2/ARE pathway also enhances the activation of HO-1 and NADPH-quinone oxidoreductase 1 (NQO1) in diabetic retinopathy [71], which might be the underlying molecular mechanism by which SETD7 protects against MIRI [64]. The gene discussed is SETD7; the disease is diabetic retinopathy.