UGT1A1 and Decreased total neutrophil count: Results showed that UGT1A1*6 mutations are related to hyperbilirubinemia, how much and whether to reduce the dose, the degree of vomiting, the severity of diarrhea, and the severity of neutropenia, which shows that the patients with UGT1A1*6 heterogeneous mutation may be more likely to cause severe vomiting, diarrhea, and neutropenia, as well as hyperbilirubinemia.