Second, multivariate Logistic regression analysis showed that the presence or absence of vomiting and mucositis was more related to the UGT1A1*28 heterogeneous mutation, and severe vomiting and severe neutropenia were more common in patients with heterogeneous mutation of UGT1A1*6. Third, to further clarify whether there is a difference in the adverse reaction spectrum between colorectal cancer and panneoplastic species, we performed multivariate Logistic regression analysis on 107 panneoplastic patients and 66 patients with simple colorectal cancer after adjusting for multiple variables. Here, UGT1A1 is linked to neutropenia.