UGT1A1 and Hyperbilirubinemia: After adjusting the six variables including treatment line, treatment regimen, smoking, gender, tumor type and hyperbilirubinemia, multivariate Logistic regression analysis showed that UGT1A1*6 was significantly correlated with the presence or absence of vomiting, the severity of vomiting and diarrhea, and UGT1A1*28 was significantly correlated with the severity of vomiting (Tab 4).