In the virus–host interaction, host cells actively respond to viral infection by impairing m6A demethylation activity of ALKBH5 through demethylating R107 residue in protein, leading to the increased mRNA degeneration and inhibited protein expression of Oxoglutarate Dehydrogenase (OGDH), limiting the TCA cycle and cellular metabolism in host cells, thus restricting viral infection.58 The gene discussed is OGDH; the disease is viral infectious disease.