It was also revealed that compared with the miR-181a-5p mimics group, the apoptosis of RB cells was remarkably reduced in the miR-181a-5p mimics+pcDNA-NRAS group, and the apoptosis was remarkably higher in the miR-181a-5p inhibitor+si-NRAS group than that in the miR-181a-5p group (Fig. 5I). This evidence concerns the gene NRAS and retinoblastoma.