For instance, miR-124 was found to be significantly downregulated in RB tissues and cell lines, and in vitro assays revealed that miR-124 suppresses the proliferation, migration, and invasion of RB cells and induces apoptosis by targeting Signal Transducer and Activator of Transcription (STAT)-3;4 miR-25-3p is found to be significantly increased in RB tissues and cell lines. The gene discussed is STAT3; the disease is retinoblastoma.