Baseline ET-1 levels (pg/ml) were also significantly elevated in subgroups of patients that died (2.09 [1.66–3.15]), developed acute kidney (1.70 [1.07–2.36]) or myocardial injury (1.50 [0.92–2.28]) compared with patients with an uncomplicated infection (1.00 [0.61–1.57], p ≤0.01) for whom these endpoints were not recorded (Fig. 1A). This evidence concerns the gene EDN1 and infection.