Amongst the infected patients, baseline ET-1 was a significant independent predictor of hospitalisation in a multivariate binary logistic regression model including hypertension, ischemic heart disease, diabetes, congestive cardiac failure and chronic kidney disease (odds ratio [95%CI]: 4.5 [1.8–11.2], p = 0.001 - appendix). This evidence concerns the gene EDN1 and chronic kidney disease.