CALR and neoplasm: Specifically, DOX‐induced chemotherapy could cause tumor immunogenic cell death (ICD), manifesting the release of high‐mobility group box 1 (HMGB1) and the expose of calreticulin (CRT) on the cell membrane, resulting in an antitumor immune response to maximize the immune‐regulation effects from mannose (Ma, Yang, et al., 2021).