After adjusting for age, gender, NIHSS score, ASPECT score, stenting, site of artery occlusion, and etiology of stroke, a multivariate regression analysis revealed that 24‐h serum occludin levels >4.95 ng/ml were an independent risk factor for poor prognosis (Barthel index ≤ 80) for stroke patients who undergone successful thrombectomy (OR = 5.48, 95% CI: 1.36–22.08, p = 0.017), see Table S1. The gene discussed is OCLN; the disease is Stroke.