LRRFIP1 and central nervous system cancer: mRNA expression of LRRFIP1 was almost negatively correlated with methylation levels in gliomas, which was consistent in the discovery dataset (TCGA 27K methylation dataset, TCGA microarray, n = 256, R = −0.41, p < 0.0001; TCGA RNAseq, n = 76, R = −0.27, p < 0.05) and validation datasets (CGGA 27K methylation dataset, CGGA microarray, n = 20, R = −0.41, p < 0.1; TCGA 450K methylation dataset, TCGA microarray, n = 90, R = −0.24, p < 0.05; TCGA RNAseq, n = 54, R = −0.45, p < 0.001) (Figure 2A–E).