IRF8 and viral infectious disease: The newly identified patient with AR complete IRF8 deficiency described here presented clinical and immunological features common to the other three patients reported [8–11]: susceptibility to severe infectious disease (including BCG-osis following exposure to BCG vaccine and viral infections), intracerebral calcifications [8–10], and absence of circulating monocytes [8–11] and DCs [8–10], with massive neutrophilia [8–11].