UPF1 and hepatocellular carcinoma: Therefore, we constructed SNHG5-wild-type(WT) and SNHG5-mutant (Mut) RNA probes (Fig. 3K) and performed RNA-pulldown experiments, the pullsown result showed that UPF1 binds to SNHG5 in HCC CSCs (Fig. 3L).These observations suggested that SNHG5 binds to UPF1 and inhibits UPF1 expression in HCC CSCs.