The present study aims to analyze the effect of SNHG5 on the proliferation and establish the cancer stem cell-like properties of HCC, explore the function of the SNHG5 in regulating the properties of HCC CSCs through UPF1 and Wnt-signaling pathway in vitro, and in promoting tumorigenesis in vivo. Here, UPF1 is linked to hepatocellular carcinoma.