Hutchinson Gilford progeria syndrome (HGPS) is caused by a dominant mutation at the splicing site in LMNA, resulting in the expression of progerin, whose C-terminal tail is altered from normal lamin A. Progerin remains farnesylated at the altered C-terminal end, unlike the mature form of wild-type lamin A/C24. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.