However, re-analysis of PD patients treated with a GDNF analog (Fig. 3 in Olanow et al.40), neurturin gene therapy, who were less than 5 years beyond PD diagnosis, did show a significant improvement compared to placebo (-14 points UPDRS-3, 40% change, Table 1)40. The gene discussed is GDNF; the disease is Parkinson disease.