PTEN and colorectal carcinoma: Interestingly, the prevalence of PTEN mutations is higher in CRC tumors from females than from males in the MT-L subset, but higher in males than females in the MSS-htmb subset (p = 2 × 10−17 and 0.03, respectively); there was no significant difference for PTEN mutation prevalence based on sex in the MT-H subset (Fig. 2d, Supplementary Table 5).