PTEN and neoplasm: Based on VAMP-seq analyses (Fig. 6b, Supplementary Fig. 10c, d; Supplementary Table 22), and using a cut-off score of 0.4 (as in43,44) to indicate a significant effect, about half (54–58%) of PTEN mutations reduce protein abundance in all CRC cohorts, without significant variation based on tumor subsite, age, or sex.