Interestingly, although both the SBS1 and IDT signatures have been described as “clock-like”32,35, accumulating as a factor of age, an age-associated increase in these signatures among PTEN mutations was not observed in either the MT-L or MT-H cohorts in spite of the overall increase in PTEN mutations in these tumor groups (Fig. 4b and Supplementary Table 17). Here, PTEN is linked to neoplasm.