Variants in IDH1 (r2 = 0.751, P = 0.0012), IDH2 (r2 = 0.986, P < 0.0001), EZH2 (r2 = 0.918, P = 0.003), TP53 (r2 = 0.774, P = 0.0018), NPM1 (r2 = 0.106, P = 0.11), and RUNX1 (r2 = 0.196, P = 0.13) showed uniformity between primary AML and PDX BM cells (Fig. 2e, f and Supplementary Fig. 1a). This evidence concerns the gene RUNX1 and acute myeloid leukemia.